Trial Reporting and the Human Studyome Project

The Trial Bank Project (summarized here) moved away from pursuing trial bank publishing to explore new research avenues for several reasons. First, the registration of clinical trials into national registers like became a global policy. Dr. Sim led the establishment of this policy when she was the founding Project Coordinator of the International Clinical Trials Registry Platform at the World Health Organization. Second, the FDA Amendments Act of 2007 required the reporting of basic results into This greatly welcomed worldwide effort to make trial registration and reporting required means that setting up and running trial registers and results reporting websites has become an administrative and operational effort, rather than a research one. The sharing and re-use of human studies data for large-scale high-throughput computation of what we are calling the human studyome (the totality of all human studies worldwide) became then the real scientific opportunity.

Our efforts were first aimed at collecting study information from as early in the study lifecycle as possible, and to ensure the distributed data sharing of human studies design and results information from multiple database using the shared semantics of the Ontology of Clinical Research. 

Now our efforts are in developing and launching Vivli, a global clinical trial data sharing platform.

The Trial Bank Project's work focused on two major areas:

  1. The Ontology of Clinical Research (OCRe), a reference ontology for the interpretation of human studies
  2. HSDBgrid, a caGrid-based architecture for federated data-sharing of human studies data using OCRe as the reference semantics, with participation of 15 major US academic medical centers

The applications developed by the Trial Bank Project were:

  • RCT Presenter (a subset of pages is available for browsing)
  • Bank-a-Trial (no longer available online; you can view the underlying model, RCT Schema)

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